急性肺损伤(ALI)和急性呼吸窘迫综合征(ARDS)发病机制复杂,病死率高,是临床常见的棘手的呼吸系统急危重症。各种肺内外因素引起多种炎症介质的释放,引发肺内过度、失控的炎性反应,形成恶性循环,使机体损伤加重。越来越多的证据表明,单核-巨噬细胞在ALI/ARDS发病中起着重要的作? Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) have complicated pathogenesis and high mortality rate, and are the most common respiratory diseases in critically ill patients. A variety of pulmonary factors lead to the release of a variety of inflammatory mediators, triggering the lung excessive, uncontrolled inflammatory reaction, the formation of a vicious circle, so that the body injury increased. More and more evidence shows that mononuclear macrophages play an important role in the pathogenesis of ALI / ARDS.