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脾肿大在急性原淋巴细胞白血病(ALL)患者起病时常见的是由白血病性原始细胞浸润所致。在缓解-诱导治疗后脾肿大持续存在,或在维持治疗期间出现脾大,通常认为是疾病复发的证据。本文描述5例ALL 患儿在血液学缓解期脾大持续存在,并讨论其意义。男性3例,女性2例,年龄4～12岁。3例分别在缓解诱导后1月、4月和3.5年首次发现脾大,2例在缓解诱导后持续性脾大。脾最大时在肋缘下2～6cm。3例作了脾切除,组织学检查均无白血病浸润.其中2例在切脾前有1次复发。这3例分别在术后10、12和28个月死于复发。未作脾切除的2例尚存活,自查出脾大
Splenomegaly is common in patients with acute lymphoblastic leukemia (ALL) onset is caused by the infiltration of leukemia blasts. Splenomegaly persists after remission-induction therapy, or splenomegaly occurs during maintenance therapy and is generally considered evidence of a relapse. This article describes the 5 cases of ALL children in the hematological remission splenomegaly persistence, and discuss its significance. 3 males and 2 females, aged 4 to 12 years old. Three cases were found splenomegaly for the first time in January, April and 3.5 years after induction of remission, and persistent splenomegaly in 2 cases after remission induction. The largest spleen in the ribs 2 ~ 6cm. 3 cases were splenectomy, histological examination without leukemia infiltration, including 2 cases before splenectomy there is a recurrence. These three patients died of recurrence at 10, 12 and 28 months after surgery. Two cases without splenectomy survived, since the splenomegaly was found