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目的探讨胃肠乐(由党参、白术、田七、丹参、香附等组成)促进溃疡修复愈合的效应及其可能的机制。方法48只大鼠随机分为正常对照组、模型对照组及胃肠乐高、中、低剂量组和洛赛克组,复制乙酸慢性胃溃疡模型后给药12d,计算各组溃疡指数,免疫组化法检测胃粘膜组织热休克蛋白70(HSP70)、热休克蛋白27(HSP27)的表达。结果胃肠乐高、中、低剂量组及洛赛克组胃粘膜溃疡指数均较模型对照组明显下降(P<0.01)。胃肠乐高、中、低剂量组胃粘膜HSP70、HSP27的表达均较模型对照组显著增强(P<0.05)。结论胃肠乐可促进乙酸慢性胃溃疡大鼠溃疡的愈合,提高溃疡愈合质量,此作用可能与其促进胃粘膜组织表达HSP70、HSP27有关。
Objective To investigate the effect of gastrointestinal music (composed of Codonopsis pilosula, Atractylodes, Tianqi, Salvia miltiorrhiza and Cyperus rotundus) on the ulcer healing and its possible mechanism. Methods Forty-eight rats were randomly divided into normal control group, model control group, gastrointestinal LEG, middle and low dose group and Losec group, which were treated with chronic gastric ulcer model of acetic acid for 12 days. The ulcer index, Gastric mucosal tissue heat shock protein 70 (HSP70), heat shock protein 27 (HSP27) expression. Results Gastric ulcer, moderate and low dose group and the Losec group gastric ulcer index were significantly lower than the model control group (P <0.01). The expressions of HSP70 and HSP27 in gastric mucosa of gastrointestinal LEG, medium and low dose groups were significantly higher than those of model control group (P <0.05). Conclusion Gastrointestinal music can promote the healing of ulcer in rats with chronic gastric ulcer and improve the quality of ulcer healing. This effect may be related to the promotion of gastric mucosal expression of HSP70 and HSP27.