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研究了诺氟沙星与β-环糊精(简称β-CD)及其两种衍生物羟丙基-β-环糊精(简称Hp-β-CD)、甲基-β-环糊精(简称Me-β-CD)形成的超分子体系。利用荧光光谱法测定了超分子体系的包结常数和包结比,及其热力学参数。诺氟沙星与3种环糊精均形成1∶1稳定的包合物,诺氟沙星与β-CD、Me-β-CD及Hp-β-CD作用的包结常数分别为94.36、33750mol-1.L和10500mol-1.L;热力学结果表明ΔH和ΔS均减小。诺氟沙星与β-CD衍生物的包结能力大于其与母体β-CD的包结能力。20℃时诺氟沙星与β-CD,Me-β-CD及Hp-β-CD能够自发形成超分子体系。
The effects of norfloxacin and β-cyclodextrin (β-CD) and its two derivatives hydroxypropyl-β-cyclodextrin (Hp-β-CD) (Me-β-CD) formed by the supramolecular system. The inclusion constants and entrapment ratios of the supramolecular system and their thermodynamic parameters were measured by fluorescence spectroscopy. Norfloxacin and 3 cyclodextrins all formed a 1: 1 stable inclusion complex. The inclusion constants of norfloxacin with β-CD, Me-β-CD and Hp-β-CD were 94.36, 33750mol-1.L and 10500mol-1.L; thermodynamic results show that both ΔH and ΔS decrease. Encapsulation ability of norfloxacin and β-CD derivatives is greater than that of β-CD. Norfloxacin and β-CD, Me-β-CD and Hp-β-CD spontaneously formed supramolecular system at 20 ℃.