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采用流行病学、血清学和病原学方法对我省出血热重点流行区的类型进行了调查，明确是以姬鼠型为主的疫区。为此，选择ＨＦＲＳ沙鼠肾细胞Ⅰ型灭活疫苗为本次观察考核的疫苗。对人间疫情和鼠间感染情况进行多次监测，确定淮河流域上段ＨＦＲＳ稳定的重疫区为试点，并按发病率和估计疫苗的保护率确定了试点样本含量。共确定２万余人为观察对象，经个体随机方法，确定了接种组和对照组，经均衡试验检测Ｐ＞０．０５，两组选择是满意的。经过１年观察，该苗有良好的抗原性，全程接种后１４天ＩＦＡ抗体阳转率达９５．１５％（５８／６２），ＧＭＴ为３２．３８，抗体水平持续３～６个月，首次接种后３６０天加强注射阳转率亦可达９０％以上；ＭＣＰＥＮＴ抗体阳转率仅为５４．１７％（１３／２４），ＧＭＴ为１６．１６。１０７９３人全程接种后未发现全身严重异常反应，反应率在１．０％以下，对人群是安全的，并有良好的免疫应答；在１年观察中接种组无一例患者发生，对照组发病率为１２３．８／１０万，保护率为１００％，证实近期流行病学防病效果非常理想。
Epidemiological, serological and etiological methods were used to investigate the types of endemic areas of haemorrhagic fever in our province. To this end, choose HFRS gerbil kidney cell type I inactivated vaccine for the observation and evaluation of the vaccine. The epidemic situation and the mouse infection were monitored many times to determine the stable HFRS epidemic in the upper Huaihe River Basin as a pilot project. The pilot sample content was determined according to the incidence rate and the estimated vaccine protection rate. A total of more than 2 people were identified as the observation object, by an individual random method to determine the vaccination group and the control group, the equilibrium test to detect P> 0.05, the two groups are satisfied. After one year of observation, the seedlings had good antigenicity. The IFA antibody positive rate reached 95.15% (58/62), the GMT was 32.38 and the antibody level continued for 3 to 6 months after the full vaccination for 14 days After 360 days of vaccination, the rate of positive injection could reach more than 90%. The positive rate of MCPENT antibody was only 54.17% (13/24) and the GMT was 16.16.10793 No serious systemic abnormality was found after inoculation , The response rate of 1.0% or less, is safe to the population, and has a good immune response; in the 1-year observation of vaccination group, no patient occurred, the incidence of the control group was 123.8 / 100,000, the protection rate was 100%, confirmed the recent epidemic prevention effect is very good.