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细胞外囊泡(extracellular vesicles,EVs)是细胞旁分泌产生的一种亚细胞成分,主要分为外泌体(exosome)、微囊泡(microvesicle)两种类型,正常细胞和肿瘤细胞均可分泌EVs。肺癌细胞分泌的EVs参与肺癌生物学功能和肿瘤微环境调节,对肺癌的发生发展发挥重要作用。由于EVs包含的物质及特殊的分子结构决定其在肺癌的早期诊断、作为免疫调节剂、化疗药物载体等方面具有独特的临床应用价值,因此本篇综述主要介绍肺癌中EVs研究的进展,为肺癌的早期诊断、治疗及预后提供重要的依据。
Extracellular vesicles (EVs) are a kind of subcellular components produced by cell paracrine. They are mainly divided into exosomes and microvesicles. Normal cells and tumor cells can be secreted EVs. EVs secreted by lung cancer cells are involved in the biological function of lung cancer and regulation of tumor microenvironment, and play an important role in the occurrence and development of lung cancer. Because EVs contains substances and special molecular structure that determine its early diagnosis of lung cancer, as an immunomodulator, chemotherapy drug carrier has a unique clinical application value, this review focuses on the progress of EVs in lung cancer research, lung cancer Early diagnosis, treatment and prognosis provide an important basis.