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目的 :探讨食管鳞状上皮细胞癌细胞凋亡临床病理意义。方法 :用TUNEL技术免疫组化染色 ,观察30例食管鳞状上皮细胞癌细胞凋亡情况 ,用 10例食管正常鳞状上皮细胞作为对照研究 ,分析它们与食管鳞状上皮细胞癌临床病理因素的关系。结果 :从食管正常鳞状上皮细胞、食管鳞状上皮细胞不典型增生及食管鳞状上皮细胞癌 ,细胞凋亡逐渐减少 ,食管鳞状上皮细胞癌和食管鳞状上皮细胞重度不典型增生的细胞凋亡与食管正常鳞状上皮细胞凋亡比较 ,差异均有显著性 (P <0 .0 1)。结论 :细胞凋亡的异常在食管鳞状上皮细胞癌的发生发展过程中起重要作用 ,且检测细胞凋亡对早期食管癌的判断和食管鳞状上皮细胞癌的病理分级具有指导意义。
Objective: To investigate the clinicopathological significance of esophageal squamous cell carcinoma cell apoptosis. Methods: TUNEL technique was used to detect the apoptosis of esophageal squamous cell carcinoma (ESCC) in 30 cases and 10 normal esophageal squamous epithelial cells were used as a control study to analyze the relationship between them and clinicopathological parameters of esophageal squamous cell carcinoma relationship. Results: From the normal esophageal squamous epithelium, esophageal squamous cell atypical hyperplasia and esophageal squamous cell carcinoma, apoptosis gradually decreased, esophageal squamous cell carcinoma and esophageal squamous cell severe dysplasia cells Apoptosis and normal esophageal squamous cell apoptosis comparison, the difference was significant (P <0.01). CONCLUSION: Abnormal apoptosis plays an important role in the carcinogenesis and progression of esophageal squamous cell carcinoma, and it is instructive to detect the apoptosis of esophageal squamous cell carcinoma and determine the pathological grade of esophageal squamous cell carcinoma.