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目的比较小剂量米非司酮和去氧孕烯炔雌醇治疗围绝经期功能失调性子宫出血的临床疗效。方法对110例围绝经期功血患者分别给予米非司酮和去氧孕烯炔雌醇治疗,对疗效进行分析比较。结果米非司酮组治疗有效率84.6%,去氧孕烯炔雌醇组治疗有效率84.4%,2组差异无统计学意义(P>0.05);2组治疗后子宫内膜明显变薄,差异均有显著意义(P<0.05)。2组不良反应均轻微。结论米非司酮和去氧孕烯炔雌醇治疗围绝经期功能失调性子宫出血的临床效果相当,长期应用米非司酮应注意其安全性。
Objective To compare the clinical efficacy of low dose mifepristone and deoxygestrel ethinyl estradiol in the treatment of dysfunctional uterine bleeding in perimenopausal period. Methods 110 cases of climacteric patients with dysfunctional uterine bleeding were given mifepristone and deoxynivalenol ethinyl estradiol treatment, the efficacy of the analysis and comparison. Results The effective rate of 84.4% in the mifepristone group and 84.4% in the desogestrel-ethinyl estradiol group was no significant difference (P> 0.05). The endometrium of the two groups was significantly thinner, The difference was significant (P <0.05). 2 adverse reactions were mild. Conclusions The clinical effects of mifepristone and deoxygregnaene ethinyl estradiol in treating peri-menopausal dysfunctional uterine bleeding are comparable. Long-term use of mifepristone should pay attention to its safety.