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目的 探讨膀胱移行细胞癌中碱性成纤维细胞生长因子 (bFGF)的表达及其与临床病理指标的关系。方法 采用免疫组织化学方法 ,对 8例正常膀胱组织及 62例原发性膀胱移行细胞癌中的bFGF进行检测。结果 膀胱移行细胞癌组织中bFGF阳性表达率为 46.8%。低分化癌和浸润性癌中的bFGF阳性表达率明显高于高分化癌和浅表性癌 (P <0 .0 5 ) ,复发者的阳性表达率明显高于未复发者 (P <0 .0 5 ) ,bFGF阳性表达者 3年生存率明显低于阴性表达者 (P <0 .0 5 )。结论 bFGF表达对膀胱移行细胞癌的生物学行为有重要影响 ,bFGF表达有可能成为预测膀胱移行细胞癌复发、转移和预后的 1项指标。
Objective To investigate the expression of basic fibroblast growth factor (bFGF) in bladder transitional cell carcinoma and its relationship with clinicopathological parameters. Methods Immunohistochemistry was used to detect bFGF in 8 cases of normal bladder tissue and 62 cases of primary bladder transitional cell carcinoma. Results The positive rate of bFGF in bladder transitional cell carcinoma was 46.8%. The positive rate of bFGF in poorly differentiated carcinoma and invasive carcinoma was significantly higher than that in well differentiated carcinoma and superficial carcinoma (P <0.05). The positive rate of bFGF in recurrence was significantly higher than that in non-relapse (P <0.05). The 5-year survival rate of bFGF positive expression was significantly lower than that of negative expression (P <0.05). Conclusions The expression of bFGF has an important influence on the biological behavior of transitional cell carcinoma of the bladder. The expression of bFGF may be an index to predict the recurrence, metastasis and prognosis of transitional cell carcinoma of the bladder.