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目的研究老年2型糖尿病合并冠心病患者心率变异性(HRV)与心脏自主神经病变关系。方法单纯2型糖尿病患者31例(Ⅰ组),2型糖尿病合并冠心病患者30例(Ⅱ组),健康对照组31例(Ⅲ组),动态心电图检测每例HRV时域指标,三组对比分析。结果三组HRV降低发生率分别为48.4%、73.3%、3.2%,差异具有统计学意义;三组SDNN、SDANN Index、SDNN Index各组间比较差异均具有统计学意义;rMSSD、PNN50Ⅱ组与Ⅲ组比较差异具有统计学意义,Ⅰ组与Ⅲ组比较差异无统计学意义。结论老年2型糖尿病合并冠心病患者HRV显著降低,较单纯2型糖尿病患者,迷走神经功能损害更重。
Objective To study the relationship between heart rate variability (HRV) and cardiac autonomic neuropathy in elderly type 2 diabetic patients with coronary heart disease. Methods Thirty-one patients with type 2 diabetes mellitus (group Ⅰ), 30 patients with type 2 diabetes mellitus with coronary heart disease (group Ⅱ) and 31 healthy controls (group Ⅲ) were enrolled in the study. analysis. Results The incidences of HRV in the three groups were 48.4%, 73.3% and 3.2%, respectively. The differences were statistically significant. The differences of SDNN, SDANN Index and SDNN Index between the three groups were statistically significant. The differences of rmsSD, PNN50Ⅱ and Ⅲ The difference between the two groups was statistically significant. There was no significant difference between group Ⅰ and group Ⅲ. Conclusion The HRV of elderly patients with type 2 diabetes mellitus complicated with coronary heart disease is significantly lower than that of patients with type 2 diabetes mellitus.