慢性肾功能衰竭(CRF)是多种肾脏疾病持续进展的最终结局,是一种进行性的临床综合征。非透析疗法是治疗CRF的有效手段之一,对CRF早、中期的疗效更为明显。自60年代许锡彦首先报道以大黄通腑治疗CRF后,各地陆续开展了此方面研究。CRF时肾小球系膜细胞增殖,基质增多,间质纤维化,以 Chronic renal failure (CRF) is the final outcome of sustained progression of multiple kidney diseases and is a progressive clinical syndrome. Non-dialysis treatment is one of the effective methods to treat CRF, and the efficacy of CRF is more obvious in the early and middle stages. Since Xu Xiyan first reported in the 1960s that he had treated CRF with rhubarb Tongtong, various researches have been conducted in this area. The glomerular mesangial cell proliferation, matrix increase, interstitial fibrosis in CRF