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目的观察蛙皮素在人胃癌和大肠癌中的表达、定位与肿瘤生物学行为的相关性。方法1997年1月至2000年12月收集中国医科大学附属第一医院人胃癌和大肠癌组织,采用链霉菌抗生物素蛋白-过氧化物酶方法(S-P方法),观察蛙皮素在胃癌及大肠炎组织以及正常胃肠组织中的表达。结果131例胃癌组织中,92例蛙皮素呈阳性表达;其癌旁黏膜中有4例染色阳性。146例大肠癌中,111例有蛙皮素的阳性表达,而在癌旁黏膜未见表达。结论蛙皮素在人胃癌和结肠癌组织中过度表达,推测可能与癌发生和细胞分化有关。
Objective To investigate the correlation between the expression and localization of bombesin in human gastric cancer and colorectal cancer and its biological behavior. Methods From January 1997 to December 2000, we collected human gastric cancer and colorectal cancer tissues from the First Affiliated Hospital of China Medical University. Streptomyces avidin-peroxidase (SP method) was used to observe the effects of bombesin on gastric cancer and Colitis tissue and normal gastrointestinal tissue. Results Among 131 cases of gastric carcinoma, 92 cases were positive for bombesin and 4 cases were positive for paracancerous mucosa. In 146 cases of colorectal cancer, 111 cases had positive expression of bombesin, but no expression in adjacent mucosa. Conclusion Bombyxins are overexpressed in human gastric cancer and colon cancer tissues, which may be related to carcinogenesis and cell differentiation.