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目的探讨原发性高血压(EH)微量白蛋白尿(MAU)与颈动脉粥样硬化(CAS)及程度的关系。方法121例住院原发性高血压患者根据颈动脉超声的结果分为颈动脉粥样硬化组(CAS组)59例及颈动脉正常组(对照组)62例。所有患者均测定尿微量白蛋白水平,并对结果进行分析。结果颈动脉粥样硬化组的尿微量白蛋白水平显著高于对照组(P<0.001),且尿微量白蛋白水平与颈动脉粥样硬化程度(硬化斑块指数)呈正相关(P<0.01)。结论原发性高血压患者尿微量白蛋白水平与颈动脉粥样硬化及硬化程度密切相关,尿微量白蛋白水平越高,颈动脉粥样病变越严重,微量白蛋白尿可能成为动脉粥样硬化及硬化程度独立危险因素。
Objective To investigate the relationship between microalbuminuria (MAU) and carotid atherosclerosis (CAS) and the degree of essential hypertension (EH). Methods 121 cases of hospitalized patients with essential hypertension were divided into carotid atherosclerosis group (CAS group) and carotid artery normal group (control group) 59 cases according to the results of carotid ultrasound. Urine microalbumin levels were measured in all patients and the results analyzed. Results The level of urinary albumin in carotid atherosclerosis group was significantly higher than that in control group (P <0.001), and the level of microalbuminuria was positively correlated with the degree of carotid atherosclerosis (plaque index) (P <0.01) . Conclusions Urine microalbuminuria in patients with essential hypertension is closely related to the degree of carotid atherosclerosis and sclerosis. The higher the level of urinary microalbuminuria, the more serious the carotid atherosclerosis, and the microalbuminuria may be atherosclerosis And degree of hardening independent risk factors.