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目的探讨周围型肺癌螺旋CT(spiral computed tomography,SCT)表现特征与癌组织中增殖细胞核抗原(proliferating cellnuclear antigen,PCNA)表达之间的关系。方法对22例经手术病理证实且行SCT平扫和增强扫描的中心型肺癌病灶进行回顾性分析,用免疫组化SP法检测肿瘤组织PCNA的表达,并计算其增殖指数(PI指数),将周围型肺癌的SCT表现特征与免疫组化结果进行对照分析。结果PCNA在中心型肺癌组织中的阳性表达率为95.5%,22个病灶PI指数的平均值为(50.75±25.80)%。周围型肺癌SCT图像上瘤体大小、纵隔淋巴结增大、深分叶征、棘突征、血管集束征及胸膜凹陷征与PCNA有相关性(P<0.05);毛刺征、空洞征、支气管气像以及肿瘤的强化程度与PCNA无明显相关性(P>0.05)。结论SCT的表现特征在一定程度上可反映周围型肺癌中PCNA的表达及细胞增殖情况。
Objective To investigate the relationship between the characteristics of spiral computed tomography (SCT) and the expression of proliferating cell nuclear antigen (PCNA) in peripheral lung cancer. Methods Twenty-two cases of central lung cancer lesions confirmed by surgery and pathology and underwent plain and enhanced SCT were retrospectively analyzed. The expression of PCNA in tumor tissue was detected by immunohistochemical SP method, and its proliferation index (PI index) was calculated. SCT features of lung cancer were compared with immunohistochemical results. Results The positive expression rate of PCNA in central lung cancer was 95.5%, and the mean value of PI index in 22 lesions was (50.75±25.80)%. The tumor size, mediastinal lymph node enlargement, deep leaf lobulation sign, spinous process sign, vascular convergence sign, and pleural pleural sign were correlated with PCNA in peripheral lung cancer on SCT images (P<0.05); burr sign, void sign, bronchial air There was no significant correlation between the degree of tumor enhancement and PCNA (P>0.05). Conclusion The expression characteristics of SCT can reflect the expression of PCNA and cell proliferation in peripheral lung cancer to some extent.