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目的 探讨 2型糖尿病及其血管并发症患者血浆D 二聚体变化。方法 选择 2型糖尿病患者 5 2例 ,将其分为有血管并发症组和无血管并发症组 ,采用ELISA方法 ,分别测定血浆D 二聚体水平。结果 糖尿病患者血浆D 二聚体水平明显高于正常对照组 (P <0 0 1 ) ,伴有血管并发症的糖尿病患者血浆D 二聚体水平较无血管并发症患者显著性升高 (P <0 0 0 1 )。结论 2型糖尿病患者存在着病理性凝血和纤溶状态 ,D 二聚体测定可预示糖尿病患者血管并发症发生的危险性 ,有助于糖尿病患者血管并发症的早期诊断和预防。
Objective To investigate the changes of plasma D dimer in patients with type 2 diabetes mellitus and its vascular complications. Methods Fifty-two patients with type 2 diabetes mellitus (T2DM) were selected and divided into two groups: vascular complications group and non-vascular complication group. The level of plasma D-dimer was determined by ELISA. Results The level of plasma D dimer in diabetic patients was significantly higher than that in normal controls (P <0.01). The plasma D dimer levels in diabetic patients with vascular complications were significantly higher than those in patients without vascular complications (P < 0 0 0 1). Conclusion There is pathological coagulation and fibrinolysis in patients with type 2 diabetes mellitus. D-dimer assay can predict the risk of vascular complications in diabetic patients and contribute to the early diagnosis and prevention of vascular complications in diabetic patients.