论文部分内容阅读
目的:研究黏着斑激酶(FAK)及成纤维细胞生长因子-2(FGF-2)在鼻咽癌中的表达及其临床意义。方法:应用免疫组织化学法检测鼻咽癌及鼻咽炎组织中FAK及FGF-2蛋白表达情况,并分析其与临床病理参数的关系。结果:在鼻咽癌组织中FAK、FGF-2蛋白阳性表达率与鼻咽炎组织中的表达率比较差异均有统计学意义(均P<0.05);FAK、FGF-2蛋白的表达与淋巴结转移有关(分别P<0.01和P<0.05),与其他病理参数无关(P>0.05);FAK的表达与FGF-2的表达呈正相关(r=0.350,P<0.01)。结论:FAK、FGF-2的高表达在鼻咽癌的发生、发展中具有一定的相关性。
Objective: To investigate the expression of focal adhesion kinase (FAK) and fibroblast growth factor-2 (FGF-2) in nasopharyngeal carcinoma and its clinical significance. Methods: The expression of FAK and FGF-2 protein in nasopharyngeal carcinoma and nasopharyngitis tissues was detected by immunohistochemistry. The relationship between the expression of FAK and FGF-2 protein and clinicopathological parameters was analyzed. Results: The positive rates of FAK and FGF-2 in nasopharyngeal carcinoma were significantly different from those in nasopharyngeal tissues (all P <0.05). The expressions of FAK and FGF-2 were significantly correlated with lymph node metastasis (P <0.01 and P <0.05, respectively), but not with other pathological parameters (P> 0.05). There was a positive correlation between FAK expression and FGF-2 expression (r = 0.350, P <0.01). Conclusion: The high expression of FAK and FGF-2 has some correlation in the occurrence and development of nasopharyngeal carcinoma.