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癫痫的发病率以小儿最高,治疗困难.经有关部门批准,我们从1989年开始研究用同种胎脑组织液治疗儿童癫痫.胎脑组织液经江西省医学科学研究所实验检测中心室测定含有r-氨基丁酸等6种氨基酸;pH为6.~57.0.在抗惊厥的动物实验中,实验组小白鼠对咖啡因所致的发生惊厥的只数(9/20)明显少于对照组(17/20)(P<0.01).肌注胎脑组织液的治疗组45例癫痫患儿的总有效率(88%)高于对照组45例的总有效率(71.1%)(P<0.05).脑电图的改善率治疗组(85.7%)高于对照组(57.1%).对原发性(无病因可查、有明显家族史)、非复杂性部分发怍、病程在l年以内、发作频率较低(1月或l周发作数次)的患儿作用尤为显著(P<0.05或P<0.01).本药物在临床应用和实验研究过程中未见到毒副作用.
The incidence of epilepsy in children, the highest treatment difficulties approved by the relevant departments, we started from 1989 to study the same kind of fetal brain tissue treatment of children with epilepsy fetal brain tissue by the Jiangxi Provincial Institute of Medical Laboratory Test Center containing r- Aminobutyric acid and other six kinds of amino acids; pH was 6. ~ 57.0. In animal experiments of anticonvulsant, mice in the experimental group had significantly fewer caffeine-induced seizures (9/20) than the control group (P <0.01). The total effective rate (88%) in 45 infants with epilepsy was significantly higher than that in the control group (71.1%) (P <0.05). The EEG improvement rate was higher in the treatment group (85.7%) than in the control group (57.1%). For primary (no cause was found and obvious family history) and non-complicated part developed, the course of disease was within 1 year, The frequency of seizures was significantly lower (P <0.05 or P <0.01) in children with multiple episodes of seizures in January or one week. No toxic or side effects were observed in the clinical and experimental studies.