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目的:探讨乌司他汀对特发性肺纤维化(IPF)患者肿瘤坏死因子(TNF-α)的干预及治疗作用。方法:将我院2009年8月～2011年10月我院呼吸内科收治的IPF的30例患者,随机分为乌司他汀治疗组(n=16)和激素对照组(n=14),治疗组和对照组于治疗后第7、14、21天抽取外周血测定肿瘤坏死因子(humornecrosisfactor-α,TNF-α)及肺功能测定,比较2组TNF-α.的变化,观察肺功能变化情况。结果:治疗前2组患者外周血TNF-α均高于正常,经乌司他汀治疗后治疗组TNF-α明显低于对照组(P<0.01),经乌司他汀治疗后患者肺功能较对照组明显改善。结论:乌司他汀能有效降低IPF患者TNF-α水平,改善IPF患者的预后,乌斯他汀为临床治疗IPF的提供了新途径。
Objective: To investigate the intervention and therapeutic effect of ulinastatin on tumor necrosis factor (TNF-α) in patients with idiopathic pulmonary fibrosis (IPF). Methods: Thirty patients with IPF admitted to our hospital from August 2009 to October 2011 were randomly divided into ulinastatin group (n = 16) and hormone control group (n = 14) The levels of tumor necrosis factor (TNF-α) and lung function in peripheral blood were measured on the 7th, 14th and 21st day after treatment in the control group and the control group, and the changes of TNF-α in the two groups were compared to observe the change of pulmonary function . Results: The levels of TNF-α in the peripheral blood of the two groups before treatment were all higher than those in the normal group. The levels of TNF-α in the treatment group after ulinastatin treatment were significantly lower than those in the control group (P <0.01). After ulinastatin treatment, Group improved significantly. Conclusion: Ulinastatin can effectively reduce the level of TNF-α in patients with IPF and improve the prognosis of patients with IPF. Aesthetics provides a new way for the clinical treatment of IPF.