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一、前言 CCl_4所致的肝损伤及防治方面的研究,由于药物中毒性肝炎发病率的上升,已越来越被人们所认识和重视。国内外都在积极探讨这方面的问题。目前对于CCl_4所致肝损伤的西医治疗通常是营养、休息、保肝等常规疗法。而我国的中药在肝病治疗中的作用颇值重视。本文想就这方面做一综述。二、CCl_4所致肝损伤的机制及中药治疗 CCl_4是一种选择性肝脏毒物,引起肝细胞损伤的作用迅速而且严重。目前有两种假说用以解释CCl_4造成肝损伤的机理。一为脂质过氧化学说:这种学说认为CCl_4在体内对肝亲和力大,经肝微粒体中的细胞色素P—450
I. INTRODUCTION The study of liver damage and prevention and treatment caused by CCl_4 has been increasingly recognized and valued by people due to the increase in the incidence of toxic hepatitis. Both domestic and foreign countries are actively exploring this issue. Currently Western medicine treatment for liver injury caused by CCl_4 is usually conventional therapy such as nutrition, rest, and liver protection. The role of traditional Chinese medicine in the treatment of liver diseases is quite important. This article would like to give an overview of this aspect. Second, the mechanism of CCl_4 induced liver injury and treatment of traditional Chinese medicine CCl_4 is a selective liver poison, causing rapid and serious liver cell damage. There are two hypotheses to explain the mechanism of liver injury caused by CCl_4. One is lipid peroxygen chemistry: This theory suggests that CCl_4 has a high affinity for liver in vivo, and cytochrome P-450 in liver microsomes.