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目的分析前列地尔注射液对I型心肾综合征(CRS)患者肾脏功能的保护作用。方法将144例CRS患者随机分为研究组和对照组各72例。2组患者均给予常规综合治疗方案,研究组在对照组基础上给予前列地尔注射液10μg静脉推注,每天3次,连用7d。分别于入院第1、7天抽取2组外周静脉血检测血清肌酐(Scr)、尿素氮(BUN)、胱抑素C(Cys C),计算24h尿量及肾小球滤过率(GFR)。结果治疗后,研究组Scr、BUN、Cys C低于对照组,24h尿量及GFR高于对照组(P<0.05)。结论前列地尔注射液具有保护心肾综合征患者肾脏功能作用。
Objective To investigate the protective effects of alprostadil injection on renal function in patients with type I heart-kidney syndrome (CRS). Methods 144 patients with CRS were randomly divided into study group and control group of 72 cases. The patients in both groups were given conventional comprehensive treatment. The study group was given 10μg of alprostadil 10μg intravenously on the basis of the control group, three times daily for 7 days. Two groups of peripheral venous blood samples were taken for blood urea nitrogen (BUN) and cystatin C (Cys C) on the first day of admission to calculate the 24h urine output and glomerular filtration rate (GFR) . Results After treatment, the Scr, BUN and Cys C in the study group were lower than those in the control group, and the urine output and GFR in 24h were higher than those in the control group (P <0.05). Conclusion Alprostadil injection can protect renal function in patients with cardio-renal syndrome.