目的检测137例骨髓增殖性疾病(MPD)患者的JAK2V617F 突变情况,分析其与核型异常的关系,初步探讨其在临床诊断中的价值。方法 137例 MPD 患者为苏州大学附属第一医院江苏省血液病研究所2000年4月至2006年4月就诊患者,其中男78例,女59例,平均年龄53(12～82)岁。按照 WHO 分型诊断标准,其中真性红细胞 Objective To investigate the mutation of JAK2V617F in 137 cases of myeloproliferative diseases (MPD) and to analyze the relationship between JAK2V617F mutation and karyotype abnormality and to explore the value of JAK2V617F in clinical diagnosis. Methods A total of 137 patients with MPD were treated by Jiangsu Provincial Institute of Hematology, the First Affiliated Hospital of Soochow University from April 2000 to April 2006. There were 78 males and 59 females, with an average age of 53 to 12 years old. According to WHO classification diagnostic criteria, including true red blood cells