【摘 要】
：
HYD-PEP06,an endostatin-modified polypeptide,has been shown to produce effective anti-colorectal carcinoma effects through inhibiting epithelial--mesenchymal transition (EMT).However,whether HYD-PEP06 has similar suppressive effect on hepatocellular carci
【机 构】
：
Department of Pharmacology (the State-Province Key Laboratories of Biomedicine Pharmaceutics of Chin
论文部分内容阅读
HYD-PEP06,an endostatin-modified polypeptide,has been shown to produce effective anti-colorectal carcinoma effects through inhibiting epithelial--mesenchymal transition (EMT).However,whether HYD-PEP06 has similar suppressive effect on hepatocellular carcinoma (HCC) remained un-known.In this study,HYD-PEP06 inhibited metastasis and EMT but not proliferation in vitro.Cignal finder pathway reporter array and Western blot analysis revealed that HYD-PEP06 suppressed HCCLM3 cell metastasis and EMT by inhibiting the PI3K/AKT pathway.Moreover,HYD-PEP06 exerted anti-metastasis effects in HepG2 cancer stem-like cells (CSCs) via suppressing the WNT/β-catenin signaling pathway.Finally,in HCCLM3 tumor-bearing BALB/c nu/nu nude mice,HYD-PEP06 substantially suppressed tumor growth,lung metastasis and HCC progress.Our results suggest that HYD-PEP06 in-hibits the metastasis and EMT of HCC and CSCs as well,and thus has the potential as an agent for HCC treatment.
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