论文部分内容阅读
为研究围产期窒息对新生儿血糖及其调节激素的影响 ,对 40例窒息患儿生后 72小时进行连续血糖监测 ,同时测定血清皮质醇 (CT)、胰岛素 (INS)、胰高血糖素 (GC)和生长激素 (GH)的浓度。结果显示 ,轻度窒息对新生儿糖代谢无影响 ;重度窒息生后 6小时血糖最高 ,36小时最低 (P <0 0 1 )。 4种激素水平明显增高 (P <0 0 1 ) ,多元线性回归分析发现重度窒息后 6～ 1 2小时血糖值与CT和GC水平呈显著性正相关 (P <0 0 1 ) ,证实了新生儿重度窒息后高胰岛素血症和高血糖并存现象。结论认为 ,应激反应在新生儿重度窒息后高血糖的发生中起重要作用 ,血糖监测对重度窒息患儿十分重要 ,治疗时不宜应用糖皮质激素和胰岛素。
To study the effects of perinatal asphyxia on neonatal blood glucose and its regulatory hormones, continuous asphyxia was monitored in 40 asphyxial children at 72 hours after birth. Serum cortisol (CT), insulin (INS), glucagon (GC) and growth hormone (GH) concentrations. The results showed that mild asphyxia had no effect on neonatal glucose metabolism; blood glucose was highest at 6 hours after severe asphyxia, and lowest at 36 hours (P <0.01). The levels of 4 hormones were significantly increased (P <0.01). Multiple linear regression analysis showed that blood glucose levels at 6 to 12 hours after severe asphyxia had a significant positive correlation with CT and GC levels (P <0.01), confirming the newborn Severe asphyxia in children with hyperinsulinemia and hyperglycemia coexist. Conclusion: The stress response plays an important role in the occurrence of hyperglycemia in neonates with severe asphyxia. It is very important to monitor the blood glucose in children with severe asphyxia. Glucocorticoid and insulin should not be used in the treatment.