患者，男，３０岁，农民，因间歇性黄疸５年就诊。近５年来不明原因逐渐出现皮肤黄疸，伴尿色加深，轻度乏力，食欲不振，未引起重视，仍坚持一般体力劳动。症状时轻时重，多因劳累、饮酒而发作。无皮肤瘙痒，亦无腹泻。其侄子２年前曾诊断为Ｄｕｂｉｎ－Ｊｏｈｎｓｏｎ综合征 Patient, male, 30 years old, farmer, visited for 5 years due to intermittent jaundice. Over the past 5 years, jaundice of skin has gradually appeared for unknown reasons, with dark urine, mild fatigue, loss of appetite, which has not attracted much attention and still insists on normal physical labor. When the symptoms of light weight, mostly due to fatigue, drinking and attack. No skin itching, no diarrhea. His nephew was diagnosed with Dubin-Johnson syndrome two years ago