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目的研究短期小剂量激素治疗中老年类风湿性关节炎的临床疗效。方法根据随机数字表法对2016年1月-2017年2月收治的76例中老年类风湿性关节炎患者分组,参照组38例采用免疫抑制剂进行治疗;治疗组38例在参照组基础上给予短期小剂量激素治疗。就两组患者疼痛消失时间、恢复正常活动时间和类风湿性关节炎治疗效果进行比较,对比治疗前后血清尿酸、血沉水平、C反应蛋白水平、晨僵平均时间。结果治疗组类风湿性关节炎治疗效果明显高于参照组(P<0.05)。治疗组患者疼痛消失时间、恢复正常活动时间均明显短于参照组(P<0.05)。干预前两组血清尿酸、血沉水平、C反应蛋白水平、晨僵平均时间相近(P>0.05);干预后治疗组血清尿酸、血沉水平、C反应蛋白水平低于参照组,晨僵平均时间短于参照组(P<0.05)。结论短期小剂量激素治疗中老年类风湿性关节炎的临床疗效确切,可有效改善临床生化指标和患者症状体征,缩短疗程,值得推广。
Objective To study the clinical efficacy of short-term, low-dose hormone therapy for middle-aged and elderly patients with rheumatoid arthritis. Methods According to the random number table method, 76 cases of middle-aged and elderly patients with rheumatoid arthritis were divided into groups from January 2016 to February 2017, and the reference group was treated with immunosuppressant. In the treatment group, 38 cases were treated with the reference group Give short-term low-dose hormone therapy. On the two groups of patients with pain disappear time and return to normal activity and rheumatoid arthritis treatment were compared before and after treatment, serum uric acid, ESR level, C-reactive protein level, average morning stiffness. Results The treatment effect of rheumatoid arthritis in treatment group was significantly higher than that in reference group (P <0.05). Patients in the treatment group had significantly shorter durations of pain disappearance and normal activities than those in the reference group (P <0.05). Serum levels of uric acid, erythrocyte sedimentation rate, C-reactive protein and morning stiffness in the two groups before intervention were similar (P> 0.05). Serum uric acid, erythrocyte sedimentation rate and C-reactive protein in the treatment group were lower than those in the reference group In the reference group (P <0.05). Conclusion Short-term low-dose hormone therapy for middle-aged and elderly patients with rheumatoid arthritis has definite curative effect, which can effectively improve the clinical and biochemical indexes and symptoms and signs of patients, and shorten the course of treatment. It is worth promoting.