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目的:考察丙种球蛋白静脉滴注联合干扰素雾化吸入治疗儿童重症手足口病的临床疗效,供临床参考.方法:选取2013年1月至2016年7月我院收治的重症手足口病患儿90例,采用随机数表法分为对照组和观察组各45例.对照组采用干扰素雾化吸入治疗,观察组采用丙种球蛋白静脉滴注联合干扰素雾化吸入治疗,治疗5d后比较两组的临床疗效.结果:观察组退热时间、疱疹消失时间、口腔炎愈合时间、神经受累时间及住院时间均短于对照组(P均＜0.05).观察组治疗5d后,血清IL-6、TNF-α均低于对照组(P均＜0.05);IGF-1、CD3、CD4、CD4/CD8水平均高于对照组(P均＜0.05).观察组不良反应发生率低于对照组(P＜0.05).结论:丙种球蛋白静脉滴注联合干扰素雾化吸入治疗儿童重症手足口病效果理想,值得推广应用.“,”Objective:To observe the efficacy of gamma globulin intravenous drip combined with interferon aerosol inhalation on severe hand,foot and mouth disease (HFMD) in children.Methods:Ninety children with severe HFMD in our hospital from January 2013 to July 2016 were randomly divided into control group (n =45) and observation group (n =45).The control group received interferon aerosol inhalation,observation group received gamma globulin combined with interferon aerosol inhalation.The clinical efficacy of two groups after five days' treatment were compared.Results:The time of defervescence time,herpes disappear,stomatitis healing,nerve involvement and hospitalization of observation group were shorter than those in the control group (P＜0.05).After the treatment of 5 days,the levels of serum IL-6 and TNF-α in the observation group were lower than those of the control group (P＜0.05),and the levels of IGF-1,CD3,CD4 and CD4/CD8 were higher than those of the control group (P＜0.05).The incidence of adverse reactions in observationgroup was lower than that in control group (P＜0.05).Conclusion:Gamma globulin intravenous drip combined with interferon aerosol inhalation is effective in the treatment of severe hand,foot and mouth disease in children,and it is worthy of clinical application.