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对癌遗传基因及其产物的研究日趋深入。C-erbB,EGFR,int-2及hst-1均是临床上判断预后很有用的因子。目前认为EGFR多数存在鳞癌细胞中,但其表达程度在各细胞、组织水平间都有差异。Ozawa将32例食管癌根治术后病人的EGFR表达度分为高度表达和低度表达两组,结果生存率前者低于后者(P<0.05)。从逻辑上分析EGFR的高度表达和C-erbB癌基因的扩增是
Research on cancer genes and their products has become more and more in-depth. C-erbB, EGFR, int-2 and hst-1 are all clinically useful factors in predicting prognosis. At present, it is believed that EGFR is mostly present in squamous cell carcinoma cells, but the degree of its expression varies among cells and tissues. Ozawa divided the expression of EGFR in 32 cases of esophageal cancer patients into high expression and low expression. The survival rate of the former was lower than that of the latter (P<0.05). Logically analyzing the high expression of EGFR and amplification of the C-erbB oncogene