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目的观察自拟薄荷饮对家兔温病卫分证病理模型的治疗作用及探讨卫分阶段应用活血化瘀药的依据和意义。方法将家兔随机分为4组,银翘散组、薄荷饮组于攻毒前2 h及随后5 min,分别经腹腔注射银翘散煎液、薄荷饮煎液,观察各组家兔症状、体征,攻毒后0.5、1、1.5 h各测肛温1次,心脏采血测内皮素-1(ET-1)水平。处死动物,对主要脏器进行大体观察,并做病理镜检。结果模型组体温净增值、1.5 h体温反应指数(TRI1.5)和ET-1显著增高,肺脏轻度充血。银翘散组症状改善,体温净增值与模型组有显著差异,但体温反应指数、ET-1改变与模型组无显著差异,肺部充血无明显改善。薄荷饮组症状、各项指标、肉眼和病理观察与空白组无显著差异,而与模型组有显著差异。结论薄荷饮治疗温病卫分证能有效降低体温,改善ET-1指数和肺部充血。温病卫分证运用活血化瘀药既起到“先证而治”的作用,而且符合“微观血瘀”病理改变的治疗需要。
OBJECTIVE: To observe the therapeutic effect of self-made menthol drinking on the pathological model of Wenfenwei syndrome in rabbits and to explore the basis and significance of applying blood circulation and phlegm-resolving drugs in Weifen period. Methods Rabbits were randomly divided into 4 groups. Yinqiaosan group and Minyin group were intraperitoneally injected with Yinqiaosan decoction and Mintang decoction respectively 2 hours before and 5 minutes after challenge to observe the symptoms of rabbits in each group. , Signs, 0.5, 1 and 1.5 h after the onset of each measurement of rectal temperature, cardiac blood test endothelin-1 (ET-1) levels. The animals were sacrificed, gross observations were made on the main organs, and pathological microscopic examinations were performed. Results The model group had a significant increase in net value of body temperature, a 1.5-hour body temperature response index (TRI1.5) and ET-1, and mild lung hyperemia. The symptoms of Yinqiaosan group were improved and the net value of body temperature was significantly different from that of the model group. However, there was no significant difference in body temperature response index and ET-1 between the model group and the pulmonary hyperemia. There was no significant difference in symptoms, indicators, visual and pathological observations of the mint drinking group from the blank group, but there was a significant difference from the model group. Conclusion Minty drink can effectively reduce body temperature, improve ET-1 index and pulmonary congestion. The use of blood circulation and phlegm-resolving drugs for the syndrome of warming and disease prevention not only plays the role of “first evidence and rule”, but also meets the need of “microscopic blood stasis” for the treatment of pathological changes.