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将PD合并抑郁和焦虑症状的患者56例随机分为两组,均给予PD的常规治疗,研究组同时给予帕罗西汀片20mg,对照组给予阿米替林25mg。结果在对抑郁状态进行治疗时,治疗4、8w时研究组总有效率为50%及75%,而对照组分别为10.7%与25%;经对比,在治疗4、8w后研究组治疗总有效率均显著高于对照组。治疗4、8w后,研究组和对照组每日服用左旋多巴的用量差异显著。帕罗西汀治疗PD伴抑郁患者疗效确切,同时可减少左旋多巴用量,安全性良好。
Sixty-six patients with PD and depression and anxiety symptoms were randomly divided into two groups. All patients were given routine PD treatment. The study group was treated with paroxetine 20 mg at the same time and the control group 25 mg at amitriptyline. Results In the treatment of depression, the total effective rate was 50% in the study group and 75% in the control group at 4 and 8 weeks, while the control group was 10.7% and 25% respectively. After treatment, the total treatment group Effective rate was significantly higher than the control group. After treatment for 4 and 8 weeks, the dosage of levodopa in study group and control group was significantly different. Paroxetine treatment of PD with depression in patients with exact effect, while reducing the amount of levodopa, good safety.