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目的比较盐酸米诺环素软膏局部注入与碘甘油治疗慢性牙周炎的临床疗效。方法选取广西中医药大学第一附属医院2015年4月—2016年4月收治的慢性牙周炎患者88例,共108颗患牙,按照随机数字表法分为对照组44例(53颗患牙)和试验组44例(55颗患牙)。对照组患者给予碘甘油治疗,试验组患者给予盐酸米诺环素软膏治疗,两组患者均持续治疗4周。比较两组患者治疗前后牙龈指数、龈沟出血指数及探诊深度,临床疗效及治疗前后龈沟出血阳性率。结果治疗前,两组患者牙龈指数、龈沟出血指数、探诊深度比较,差异无统计学意义(P>0.05);治疗后,试验组患者牙龈指数、龈沟出血指数、探诊深度低于对照组(P<0.05)。试验组患者临床疗效优于对照组(P<0.05)。治疗前,两组患者龈沟出血阳性率比较,差异无统计学意义(P>0.05);治疗后,试验组患者龈沟出血阳性率低于对照组(P<0.05)。结论采用盐酸米诺环素软膏治疗慢性牙周炎临床疗效优于碘甘油,可更有效缓解患者的临床症状,减少龈沟出血。
Objective To compare the clinical efficacy of local injection of minocycline hydrochloride ointment with iodoglycerol in the treatment of chronic periodontitis. Methods A total of 88 patients with chronic periodontitis admitted to the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from April 2015 to April 2016 were selected and divided into control group (n = 44) Tooth) and experimental group 44 cases (55 teeth). Patients in the control group were given iodoglycerol, patients in the test group were treated with minocycline hydrochloride ointment, and both groups were treated for 4 weeks. Gingival index, gingival sulcus bleeding index and probing depth were compared between the two groups before and after treatment. The clinical efficacy and the positive rate of sulcus bleeding before and after treatment were compared. Results Before treatment, there was no significant difference in gingival index, sulcus bleeding index and probing depth between the two groups (P> 0.05). After treatment, the gingival index, sulcus bleeding index and probing depth of the experimental group were lower than Control group (P <0.05). The clinical efficacy of the experimental group was better than that of the control group (P <0.05). Before treatment, there was no significant difference in the positive rate of sulcus bleeding between the two groups (P> 0.05). After treatment, the positive rate of sulcus bleeding in the experimental group was lower than that in the control group (P <0.05). Conclusion The clinical efficacy of minocycline hydrochloride ointment in the treatment of chronic periodontitis is better than that of iodine glycerol, which can relieve the clinical symptoms of patients and reduce the bleeding of gingival sulcus.