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目的:评价埃索美拉唑与奥美拉唑配合抗菌药物对胃溃疡患者幽门螺杆菌的根除及其疗效。方法:选取2014年7月—2015年7月间收治的住院治疗胃溃疡患者90例作为研究对象,采用随机分组方式将其分为观察组和参照组,每组45例;对参照组患者均给予常规治疗并加奥美拉唑治疗,观察组患者均给予常规治疗加用埃索美拉唑治疗;评价两组患者治疗1月后的总有效率,以及幽门螺杆菌的根除率。结果:观察组患者治疗后的总有效率为95.56%高于参照组为77.78%(P<0.05),幽门螺杆菌的根除率为97.78%高于参照组为75.56(P<0.05)。结论:埃索美拉唑配合抗菌药物治疗胃溃疡患者的疗效与清除幽门螺杆菌效果优于奥美拉唑与抗菌药物的联用。
Objective: To evaluate the eradication and efficacy of esomeprazole and omeprazole combined with antibacterial agents against Helicobacter pylori in gastric ulcer patients. Methods: Totally 90 inpatients with gastric ulcer admitted to our hospital from July 2014 to July 2015 were selected as study subjects, and randomly divided into observation group and reference group, with 45 cases in each group. All patients in reference group Given conventional treatment plus omeprazole treatment, the observation group were given conventional therapy plus esomeprazole treatment; evaluation of two groups of patients after treatment for 1 month total efficiency, and the eradication rate of Helicobacter pylori. Results: The total effective rate was 95.56% in the observation group after treatment, 77.78% (P <0.05) in the reference group, 97.78% in the H. pylori group and 75.56 in the reference group (P <0.05). Conclusion: The efficacy of esomeprazole combined with antibacterial drugs in the treatment of patients with gastric ulcer is better than that of helicobacter pylori in removing omeprazole and antibacterial drugs.