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目的 :评价哌唑嗪、特拉唑嗪与哈乐 3种α1受体阻滞剂在治疗前列腺增生症的疗效及药物经济学效果。方法 :以开放对比的实验方法比较三种α1受体阻滞剂对 2 4 0名BPH患者主观症状与客观指标评估疗效 ,并运用药物经济学的成本 -效果分析方法进行评价。结果 :3组药物对治疗BPH均有一定的疗效。哈乐组病人无论主观症状与客观指标改善率均较佳 ,但哌唑嗪的成本效果比值远低于哈乐组及特拉唑嗪组。结论 :哌唑嗪是治疗BPH症状的一种有效、廉价的药物。
Objective: To evaluate the curative effect and pharmacological economics of three kinds of α1-blockers of prazosin, terazosin and halotile in the treatment of benign prostatic hyperplasia. Methods: To compare the subjective symptoms and objective indexes of 240 patients with BPH by comparing three kinds of α1 blockers with the open comparison experimental method, and to evaluate them with the cost-effectiveness analysis method of pharmacoeconomics. Results: The three groups of drugs have a certain effect on the treatment of BPH. Harmony group patients both subjective symptoms and objective indicators of improvement rates were better, but the cost-effective ratio of prazosin was much lower than the Hara group and terazosin group. Conclusion: Prazosin is an effective and inexpensive drug for the treatment of BPH.