近年来,口腔医学界已经公认细菌是牙周病的主要致病因子,而牙周袋内形成的大量龈下菌斑是细菌生存与繁殖的场所。但过去的研究一直认为细菌致病的机理是细菌的毒素及其产物作用于牙周组织,导致炎症和破坏的发生,而细菌本身并不能直接进入牙 In recent years, the stomatology community has recognized bacteria as the major causative agent of periodontal disease, while the large number of subgingival plaque formed within periodontal pockets is a place where bacteria survive and reproduce. However, past studies have always believed that bacterial pathogenesis is the mechanism of bacterial toxins and their products acting on periodontal tissue, leading to inflammation and destruction, and the bacteria themselves can not directly enter the teeth