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目的 对肠安康胶囊的pH依赖性进行体外释药考察。方法 以HPLC法测定盐酸小檗碱在人工胃液和人工肠液的含量为指标 ,对其pH依赖性做出体外释药初步评价。结果 肠安康胶囊采用丙烯酸树脂肠溶衣料处理 ,具有一定的延缓释药作用。在人工胃液中 1h后约释放药物 17%左右 ,在人工肠液中经 5h后基本释药完全。结论 肠安康胶囊的体外释药情况结果表明 ,本工艺是可行的 ,预计盐酸小檗碱在结肠部位可以达到浓度富集
Objective To investigate the pH-dependent release of Changankang capsules in vitro. Methods HPLC method was used to determine the content of berberine hydrochloride in artificial gastric juice and artificial intestinal fluid as indicators, and its pH dependence was evaluated in vitro. Results Intestinal Ankang capsules were treated with acrylic resin enteric coating, which had a certain delay in drug release. About 17% of the drug was released after 1 h in artificial gastric fluid, and the drug was released completely after 5 h in artificial intestinal fluid. Conclusion The results of in-vitro drug release of Chang’ankang capsules show that the process is feasible and it is expected that berberine hydrochloride can reach concentration in the colon.