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目的:观察SARS患者血清白介素-6(IL-6)含量变化。方法:用放射免疫法检测29例SARS患者血清白介素含量,与正常对照组比较。结果:进展期SARS组患者血清IL-6含量高于正常的百分率为18/29(62.1%),低于正常的百分率为3/29(10.3%)。发病后21天和病后2.5个月SARS组患者中血清IL-6含量高于正常的百分率分别为10/29(34.4%)和4/29(13.7%)。低于正常的百分率分别为3/29(10.3%)和2/29(6.9%)。重型SARS组患者进展期与发病21天后血清IL-6含量明显高于普通型SARS组。结论:SARS患者存在免疫反应异常,血清白细胞介素-6含量变化可能是SARS发病机制中一个环节。
Objective: To observe the changes of serum interleukin-6 (IL-6) in patients with SARS. Methods: Serum interleukin levels in 29 SARS patients were detected by radioimmunoassay, compared with the normal control group. Results: Serum IL-6 levels in patients with advanced SARS were 18/29 (62.1%) higher than normal and 3/29 (10.3%) lower than normal. Serum IL-6 levels were 10/29 (34.4%) and 4/29 (13.7%) higher in patients with SARS at 21 days and 2.5 months after onset, respectively. The rates below normal were 3/29 (10.3%) and 2/29 (6.9%), respectively. Serum IL-6 levels were significantly higher in patients with severe SARS than those in normal SARS patients after 21 days of onset and onset. Conclusion: There is an abnormal immune response in patients with SARS. The change of serum interleukin-6 level may be a link in the pathogenesis of SARS.