论文部分内容阅读
目的 探讨急性缺血性脑血管病患者血中性粒细胞表面细胞间粘附分子 (ICAM- 1)、血管细胞粘附分子 (VCAM- 1)和血小板上 P选择素 (CD6 2 p)的改变及其临床意义。方法 应用流式细胞术测定 12 1例脑缺血患者发病 48小时内 ICAM- 1、VCAM- 1、CD6 2 p的改变。结果 (1)各种急性脑缺血患者 ICAM- 1均较对照组升高 ,P <0 .0 1;脑血栓形成和腔隙性脑梗死 CD6 2 p升高 ,P <0 .0 5 ;脑血栓形成 VCAM- 1升高 ,P <0 .0 5。 (2 )脑梗死面积≥ 1.5 cm2 者 ICAM- 1、CD6 2 p较 <1.5 cm2 者高。 (3) ICAM - 1与收缩压呈正相关。结论 3种粘附分子在不同脑缺血患者发病初表达不同 ,测定 ICAM - 1和 CD6 2 p有助于脑缺血病情观察
Objective To investigate the changes of ICAM-1, VCAM-1 and P-selectin (CD6 2 p) on platelets in patients with acute ischemic cerebrovascular disease And its clinical significance. Methods The changes of ICAM-1, VCAM-1 and CD62p in 12 hours after onset of cerebral ischemia were detected by flow cytometry. Results (1) The levels of ICAM-1 in all kinds of acute cerebral ischemia patients were higher than those in the control group (P <0.01); the levels of CD6 2 p in cerebral thrombosis and lacunar infarction were increased (P <0.05) Cerebral thrombosis increased VCAM-1, P <0. 05. (2) ICAM-1 and CD6 2 p were higher than <1.5 cm2 in patients with cerebral infarction ≥ 1.5 cm2. (3) ICAM - 1 was positively correlated with systolic blood pressure. Conclusions The three kinds of adhesion molecules express differently in different stages of cerebral ischemia, and ICAM - 1 and CD6 2 p can be helpful for the observation of cerebral ischemia