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作者于1991年2月至1992年2月对阿姆斯特丹登记去热带或亚热带恶性疟流行区作短期旅游的荷兰人进行了追踪调查。要求每个游客在旅游期间每日服氯胍100mg,每周服氯喹300mg作为化学预防。于启程前及回国后6周内采集血样,并进行问卷调查,内容包括游客的旅游情况、发热、诊治及药物使用情况。对每份血样作R32tet_(32)-EILSA检查,测定抗环子孢子抗体,对发热者或回国后血样抗环子孢子抗体阳性者作IFAT检查,旨在评价这两种免疫学检测方法能否检出去恶性疟流行区游客中已采用化学预防药的恶性疟病例。
From February 1991 to February 1992, the authors conducted a follow-up survey of Dutch registered short-term trips to Amsterdam in tropical or sub-tropical areas of falciparum malaria. Each tourist is required to serve 100 mg of proguanil daily during the tour and chloroquine 300 mg weekly as a chemical precaution. Blood samples were taken before departure and within 6 weeks after returning home and conducted a questionnaire survey on the tourist’s travel, fever, diagnosis and treatment and drug use. Each blood sample was tested for R32tet_ (32) -EILSA, anti-cyclosporin antibodies were measured, and fever or returned anti-cyclosporin antibodies were tested for IFAT to evaluate whether these two immunological tests are available Detection of falciparum malaria endemic areas have been used in chemical prevention of falciparum malaria cases.