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目的:分析体外受精-胚胎移植(IVF-ET)后妊娠并发结核的临床特点。方法:回顾性分析2007年1月~2011年12月在兰州大学第一医院生殖中心IVF-ET后妊娠并发结核的10例临床资料。结果:IVF-ET后妊娠并发结核多发生于双胎妊娠,临床多以发热及阴道流血为主要表现。胸部影像学表现以粟粒性结节改变为主,病情凶险。4例人工流产终止妊娠,其余6例均在发病后2~4周内发生自然流产。结论:IVF-ET后妊娠合并结核的预后差,对抗炎治疗无效的发热患者应警惕结核复发,尽早行结核病的相关检查,IVF-ET术前隐性结核要提高认识,对孕期复发结核的高危人群减少移植胚胎数,尽量避免双胎妊娠。
Objective: To analyze the clinical features of pregnancy complicated with tuberculosis after in vitro fertilization-embryo transfer (IVF-ET). Methods: Ten clinical data of pregnancy complicated with tuberculosis after IVF-ET in the Reproductive Center of the First Hospital of Lanzhou University from January 2007 to December 2011 were retrospectively analyzed. Results: The incidence of complicated tuberculosis in pregnancy after IVF-ET mostly occurred in twin pregnancies. The main clinical manifestations were fever and vaginal bleeding. Chest imaging findings to change the main miliary nodules, the disease dangerous. 4 cases of abortion termination of pregnancy, the remaining 6 cases of spontaneous abortion within 2 to 4 weeks after onset. Conclusions: The prognosis of pregnancy complicated with tuberculosis after IVF-ET is poor. Patients with fever who are ineffective in anti-inflammatory therapy should be alert to the relapse of tuberculosis. The related inspection of tuberculosis should be conducted as soon as possible. The latent tuberculosis of IVF- High-risk populations reduce the number of embryos transferred, try to avoid twin pregnancies.