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目的探讨非特异性分子白介素(IL)-10和补体C3、C1q在鼻息肉中的表达及其意义。方法运用免疫组化方法检测IL-10、C3和C1q在30例鼻息肉和14例正常下鼻甲组织中的表达,对IL-10、C3和C1q阳性细胞的类型、分布进行分析。结果IL-10、C3和C1q在鼻息肉组织中表达较正常,下鼻甲组织明显增强,差异有统计学意义(P<0.01)。IL-10、C3和C1q主要表达于鼻息肉的上皮细胞及炎性细胞中。结论IL-10、C3和C1q在局部的抗感染和炎性反应中可能起着重要作用。
Objective To investigate the expression and significance of non-specific molecular interleukin (IL) -10 and complement C3 and C1q in nasal polyps. Methods The expressions of IL-10, C3 and C1q in 30 cases of nasal polyps and 14 cases of normal inferior turbinate tissues were detected by immunohistochemistry. The types and distribution of IL-10, C3 and C1q positive cells were analyzed. Results The expression of IL-10, C3 and C1q in nasal polyps was normal and the inferior turbinate tissue was significantly increased, with statistical significance (P <0.01). IL-10, C3 and C1q are mainly expressed in epithelial and inflammatory cells of nasal polyps. Conclusion IL-10, C3 and C1q may play an important role in the local anti-infective and inflammatory responses.