近来报道阿霉素可能是一种不进入细胞的细胞毒素。这种观点对肿瘤化学治疗领域内关于药物作用部位的传统观念是一种极大的挑战。实际上,这种观点是指出膜,特别是细胞表面,有可能是细胞毒性抗癌药的重要作用部位。本文摘要了细胞毒性药物与细胞膜之间相互作用的某些发现,值得重视的是,这些发现很可能促使新一代更高选择性和更高效能的抗恶性肿瘤药物的产生。 It has recently been reported that doxorubicin may be a cytotoxin that does not enter cells. This view is a tremendous challenge to the traditional notion of the site of drug action in the field of oncology chemotherapeutics. In fact, this view points to the membrane, especially the cell surface, that may be an important site of action for cytotoxic anticancer drugs. This paper summarizes some of the findings of the interactions between cytotoxic drugs and cell membranes. It is worth noting that these findings are likely to prompt the emergence of a new generation of more selective and effective anti-cancer drugs.