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目的：观察使用绒毛膜促性腺激素前后尿道下裂伴阴茎发育不良患儿的阴茎、睾丸变化，探讨此类患儿术前进行内分泌治疗的必要性。方法：对35例该病患儿采用自身用药前后对照，用药前后测量阴茎大小及睾丸体积，用药方法每次1000U，每周2次肌注，5周为一疗程，总量10000～15000U。结果：用药前阻茎平均长度1．95±0．53cm，睾丸平均体积1．55±0．96cm~3，用药后分别为3．29±0．89cm（P＜0．05），3．01±0．76cm~3（P＜0．05），2例几乎无增长，94％以上阴茎及睾丸有明显增长。结论：对尿道下裂伴阴茎发育不良患儿术前给予绒毛膜促性腺激素治疗可得到较满意的效果。
OBJECTIVE: To observe the changes of penis and testis in children with hypospadias and penile dysplasia before and after the use of chorionic gonadotrophin, and to explore the necessity of preoperative endocrine therapy in such children. Methods: 35 cases of children with the disease before and after treatment with its own control before and after treatment of penile size and testicular volume, medication method for each 1000U, 2 times a week intramuscular injection, 5 weeks for a course of treatment, the total amount of 10000 ~ 15000U. Results: The average length of stems was 1.95 ± 0.53 cm and the average testicular volume was 1.55 ± 0.96 cm ~ 3 before treatment and 3.29 ± 0.89 cm after administration (P <0.05) .3. 01 ± 0.76cm ~ 3 (P <0.05). There was almost no growth in 2 cases and more than 94% in penis and testis. Conclusion: Preoperative choriogonadotropic hormone treatment in children with hypospadias and penile dysplasia can achieve satisfactory results.