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从青花椒中提取分离出的香豆素类单体化合物香柑内酯(Bergapten,XGNZ),能明显抑制二甲苯所致小鼠耳廓肿胀及10％蛋青所致的大鼠足肿胀;有较明显的镇痛作用;能显著抑制醋酸所致小鼠的扭体反应。实验结果还证明XGNZ有非常显著地抑制小鼠腹腔毛细血管通透性的作用。
Isolation of isolated coumarin monomer Bergapten (XGNZ) from Zanthoxylum bungeanum can significantly inhibit xylene-induced mouse ear swelling and 10% egg white-induced rat foot swelling; Have obvious analgesic effect; can significantly inhibit writhing reaction in mice induced by acetic acid. The experimental results also show that XGNZ has a very significant inhibitory effect on mouse peritoneal capillary permeability.