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目的探讨心肌炎患儿通过磷酸肌酸钠与果糖二磷酸钠治疗后取得的临床疗效。方法选取2014年1月至2016年6月辽宁省盘锦市中心医院收治的60例心肌炎患儿为研究对象,随机分为观察组和对照组,各30例。对照组患儿给予果糖二磷酸钠治疗,观察组患儿采用磷酸肌酸钠进行治疗,比较两组患儿临床疗效、不良反应发生情况及治疗前后心肌酶变化情况。结果观察组治疗总有效率(93.3%)明显高于对照组(76.7%),差异有统计学意义(P<0.05);观察组不良反应发生率(6.7%)明显低于对照组(26.7%),差异有统计学意义(P<0.05);治疗后,观察组患儿乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)均明显低于对照组,差异均有统计学意义(均P<0.05)。结论心肌炎患儿通过磷酸肌酸钠与果糖二磷酸钠治疗相比,在改善患儿心肌酶状况的同时,使不良反应发生率明显降低,且治疗效果显著提高。
Objective To investigate the clinical effect of children with myocarditis treated by sodium creatine phosphate and sodium fructose diphosphate. Methods From January 2014 to June 2016, 60 cases of myocarditis in Panjin Central Hospital of Liaoning Province were selected as study subjects, and randomly divided into observation group and control group, with 30 cases in each group. Children in the control group were treated with sodium fructose diphosphate. Patients in the observation group were treated with sodium creatine phosphate. The clinical efficacy, adverse reactions and changes of myocardial enzymes before and after treatment were compared between the two groups. Results The total effective rate (93.3%) in observation group was significantly higher than that in control group (76.7%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in observation group was significantly lower than that in control group (26.7% ), The difference was statistically significant (P <0.05). After treatment, the LDH, CK and CK-MB in observation group were significantly lower than those in control group Control group, the differences were statistically significant (P <0.05). Conclusions Compared with the treatment of sodium fructose diphosphate, the incidence of adverse reactions in children with myocarditis is significantly decreased, and the therapeutic effect is significantly improved.