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本研究旨在评价肾移植受者中氟康唑对环孢素(CsA)浓度影响的程度,并证明这种相互作用是否增加肌肝水平。本研究包括16例肾移植术后至少6个月的病人,年龄18～65岁,并接受长期CsA治疗,研究前6周CsA剂量相对不变(±50mg),CsA谷值浓度>25ng/ml,而且2次血清肌肝水平相对稳定(±0.2mg%),最近一次血肌肝≤2.0mg/dl。所有化验数值保持在正常范围的10%以内,血压、脉搏、体温正常。随机双盲分为安慰剂组(Ⅰ组)和氟康唑组(Ⅱ组,200mg/d),其历时14天。CsA用量不变。第1天测出用药前,用药后1、2、4、8、12、18、24小
The aim of this study was to evaluate the extent of effect of fluconazole on cyclosporine (CsA) concentrations in renal transplant recipients and to demonstrate whether this interaction increases muscle liver levels. This study included 16 patients who were at least 6 months after renal transplantation and were 18 to 65 years old and undergoing long-term CsA. The CsA dose was relatively unchanged (± 50 mg) and the CsA trough concentration was> 25 ng / ml for the first 6 weeks of the study , And 2 times serum muscle liver level is relatively stable (± 0.2mg%), the most recent blood liver ≤ 2.0mg / dl. All laboratory values remain within the normal range of 10%, blood pressure, pulse, temperature normal. Randomized double-blind placebo group (group I) and fluconazole group (group II, 200mg / d), which lasted 14 days. CsA dosage unchanged. The first day before treatment, after treatment 1,2,4,8,12,18,24 small