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哺乳动物嗜肝DNA病毒均有一个X基因,其表达一个含约154个氨基酸的X蛋白。在HBV感染者血清检出抗-HBx能提示X基因的表达及宿主对X蛋白抗原决定簇的反应。但是,抗-HBx的检出与HBV感染的不同时期及病理损害间的关系至今各说不一。作者对急、慢性HBV感染及原发性肝细胞癌(HCC)患者进行抗-HBx检测,分析了抗-HBx检测结果与公认的病毒复制指标(血清
The mammalian hepadnavirus has an X gene that expresses an X protein of about 154 amino acids. Detection of anti-HBx in the sera of HBV-infected patients can indicate the expression of X gene and the host response to X protein epitopes. However, the relationship between the detection of anti-HBx and HBV infection at different stages and pathological damage has so far been different. The authors tested anti-HBx in patients with acute or chronic HBV infection and primary hepatocellular carcinoma (HCC) and analyzed the association between anti-HBx test results and accepted viral replication markers