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目的探讨血清胃蛋白酶原(PG)联合胃泌素17(G-17)检测在不同胃黏膜病变诊断中的临床价值。方法选取2016年3月—2017年3月于宝鸡市中心医院消化科门诊及住院收治的经胃镜及病理确诊未经治疗的胃病患者571例,根据胃镜及组织病理学检查结果分为非萎缩性胃炎组108例、萎缩性胃炎组368例、胃溃疡组29例、十二指肠溃疡组37例、复合溃疡组9例及胃癌组17例。通过酶联免疫吸附试验检测患者血清PGⅠ、PGⅡ及G-17水平,并计算PGⅠ/PGⅡ比值(PGR)。结合内镜检查及病理检查结果对比分析血清G-17、PGⅠ、PGⅡ及其比值PGR在不同胃黏膜病变中的变化情况。结果萎缩性胃炎组G-17高于非萎缩性胃炎组,胃溃疡组PGR低于非萎缩性胃炎组,十二指肠溃疡组G-17低于非萎缩性胃炎组,复合溃疡组、胃癌组PGR低于非萎缩性胃炎组(P<0.05)。十二指肠溃疡组G-17低于萎缩性胃炎组,胃癌PGR低于萎缩性胃炎组(P<0.05)。结论血清PGⅠ、PGⅡ联合G-17在检测不同胃黏膜病变的诊断中具有一定的临床应用价值。
Objective To investigate the clinical value of serum pepsinogen (PG) combined with gastrin 17 (G-17) in the diagnosis of different gastric mucosal diseases. Methods From March 2016 to March 2017, 571 gastric cancer patients were enrolled in the Department of Gastroenterology and Gastroenterology, Baoji Central Hospital, and were treated by gastroscopy and pathology. According to the results of endoscopy and histopathological examination, the patients were divided into non-atrophic 108 cases of gastritis group, 368 cases of atrophic gastritis group, 29 cases of gastric ulcer group, 37 cases of duodenal ulcer group, 9 cases of combined ulcer group and 17 cases of gastric cancer group. Serum levels of PGⅠ, PGⅡ and G-17 were detected by enzyme-linked immunosorbent assay, and PGⅠ / PGⅡ ratio (PGR) was calculated. The changes of serum G-17, PGⅠ, PGⅡ and its ratio PGR in different gastric mucosal lesions were analyzed by endoscopy and pathological examination. Results G-17 in atrophic gastritis group was higher than non-atrophic gastritis group, PGR in gastric ulcer group was lower than non-atrophic gastritis group, G-17 in duodenal ulcer group was lower than non-atrophic gastritis group, combined ulcer group, gastric cancer Group PGR was lower than non-atrophic gastritis group (P <0.05). G-17 in duodenal ulcer group was lower than that in atrophic gastritis group, PGR in gastric cancer was lower than that in atrophic gastritis group (P <0.05). Conclusion Serum PG Ⅰ, PG Ⅱ combined with G-17 in the diagnosis of different gastric mucosal lesions have some clinical value.