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目的:制备硫磺克林霉素凝胶剂并观察其临床应用效果。方法:以卡波姆为凝胶材料制备硫磺克林霉素凝胶剂,以碘量法、HPLC法分别测定硫磺和克林霉素含量,并以克林霉素磷酸酯凝胶作对照,观察临床疗效。结果:使用该制剂治疗300例寻常性痤疮患者,总有效率90.6%,明显高于克林霉素磷酸酯凝胶对照组。结论:该制剂配制简便,质量可控,疗效可靠。
Objective: To prepare sulindac clindamycin gel and observe its clinical application. METHODS: The sulindac clindamycin gel was prepared by using carbomer as the gel material. The contents of sulfur and clindamycin were determined by iodometry and HPLC. Clindamycin phosphate gel was used as the control. Observe the clinical effect. Results: The treatment of 300 cases of acne vulgaris patients with the total effective rate was 90.6%, significantly higher than the clindamycin phosphate gel control group. Conclusion: The preparation of the preparation is simple, quality control, efficacy and reliable.