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目的:探讨小剂量阿伐他汀钙片降脂效果及安全性,并对其依从性进行比较,为临床用药提供依据。方法:将60例高脂血症患者随机分为实验组和对照组各30例,实验组予每晚8:00口服阿伐他汀钙片10 mg,对照组同时间口服阿伐他汀钙片20 mg,疗程8周。治疗前、治疗4周、8周后检测低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C),每4周询问服药反应并进行实验室检测。结果:8周后治疗组LDL-C下降43.18%、HDL-C上升13.09%,对照组LDL-C下降42.66%、HDL-C上升17.75%,两组总有效率比较差异无统计学意义(P(0.05),均无不良反应或毒副作用。结论:阿伐他汀钙片10 mg每晚1次服用,安全有效,降脂效果与20 mg每晚1次相当,且依从性更好。
Objective: To investigate the lipid-lowering effect and safety of low-dose atorvastatin calcium tablets, and to compare their compliance, to provide a basis for clinical use. Methods: 60 cases of hyperlipidemia were randomly divided into experimental group and control group, 30 cases in the experimental group at 8:00 orally every night oral atorvastatin calcium 10 mg, at the same time the control group oral atorvastatin calcium 20 mg, treatment for 8 weeks. Before treatment, the treatment for 4 weeks, 8 weeks after the detection of low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), every 4 weeks medication response and laboratory tests. Results: After 8 weeks, LDL-C decreased 43.18%, HDL-C increased 13.09%, LDL-C decreased 42.66% and HDL-C increased 17.75% in the control group. There was no significant difference in the total effective rate between the two groups (0.05), no adverse reactions or side effects.Conclusion: Atorvastatin calcium tablets 10 mg taken once nightly, safe and effective, lipid-lowering effect and 20 mg per night 1 times, and better compliance.