论文部分内容阅读
在环境流行病学调查的基础上，用病区粮食及燃煤进行大鼠氟中毒模型的复制，探讨不同类型氟骨症的影响因素及发病机制，为制订有针对性的防治措施提供科学依据。实验表明：除对照组外，其余各组均出现氟斑牙；骨骼Ｘ线摄片及病理组织学检查发现，高氟组出现骨疏松，并伴有骨转换征象，加营养可减轻骨病变程度；呼吸道吸入氟也可引起氟骨症，但病变较轻。引起不同类型氟骨症的主要因素是总摄氟量高、营养低下（蛋白质及钙摄入不足）和铝元素增多等。
On the basis of environmental epidemiological investigation, the model of Fluorosis in rats was replicated with food and coal in ward to explore the influencing factors and pathogenesis of different types of skeletal fluorosis and to provide a scientific basis for the formulation of targeted prevention and treatment measures . The experimental results showed that except the control group, the other groups showed dental fluorosis. X-ray and histopathological examinations showed that osteoporosis accompanied with signs of bone turnover in high fluoride group could reduce the degree of bone lesions Respiratory fluoride inhaled can also cause skeletal fluorosis, but lessened lesions. The main factors that cause different types of skeletal fluorosis are total fluoride intake, low nutrition (insufficient protein and calcium intake) and increased aluminum.