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目的:研究舒肝降脂胶囊对高脂饲料加四氯化碳(CCl4)所致大鼠脂肪肝的治疗作用。方法:采用高脂饮食加CCl4复制大鼠脂肪肝动物模型,测定大鼠血清中总胆固醇(T-C)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、谷丙转氨酶(ALT)、谷草转氨酶(AST)含量,同时称体重、肝重、脾重和胸腺重,计算脏器系数,取肝组织测T-C、TG、丙二醛(MDA)含量并作病理观察。结果:舒肝降脂胶囊组大,中剂量给药2周能显著降低大鼠肝脏及脾脏指数,降低肝组织内T-C、TG、MDA含量,以及血清中T-C、TG、LDL-C、ALT、AST含量,升高血清中HDL-C含量,减轻肝细胞损伤及脂肪变性程度。结论:舒肝降脂胶囊对高脂饲料加CCl4所致大鼠脂肪肝具有明显的治疗作用。
Objective: To study the therapeutic effect of Shugan Jiangzhi capsule on fatty liver in rats fed with high-fat diet plus carbon tetrachloride (CCl4). METHODS: Rat fatty liver models were duplicated by high-fat diet plus CCl4. Total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol were measured in rat serum. (HDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST) content, also known as body weight, liver weight, spleen weight and thymus weight, calculating organ coefficient, taking liver tissue test TC, TG, malondialdehyde ( MDA) content and pathological observations. Results: Shugan Jiangzhi capsule group can significantly reduce liver and spleen index, reduce TC, TG, MDA content in liver tissue, and serum TC, TG, LDL-C, ALT. AST levels increase serum HDL-C levels and reduce liver cell damage and steatosis. Conclusion: Shugan Jiangzhi Capsule has obvious therapeutic effect on fatty liver of rats with high fat diet and CCl4.